منابع مشابه
Morphogen gradients: Nodal enters the stage
Morphogen gradients are proposed to organise cell fates during development via the long-range activity of secreted molecules. Their existence in vertebrates, however, has been debated. A recent study has identified the Nodal-related protein Squint as a bona fide morphogen in vertebrate mesoderm.
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SUMO enters the ring
By the mid-1990s, it was clear that conjugation to ubiquitin could affect not just a protein’s stability, but also its localization and activity. Whether there were other proteins in the cell that could also be covalently linked to substrates in order to regulate their function was unknown, at least until Matunis et al. (1), along with several other groups (2–6), identified the protein that wou...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2008
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2563